Abstract—The aim of the study was to investigate the effects of curcumin on biochemical parameters of male rats. Thirty five rats weighing 82±2 g were divided randomly into five groups. The control negative and positive groups were not being treated with curcumin. The remaining three groups were treated with curcumin by the following doses: 25 mg, 50 mg, and 100 mg /kg b. wt. / day by oral gavage for eight weeks. The results showed that curcumin treatment at dose (100 mg/kg b. wt.) significantly reduced glucose concentration, decrement in total cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL) concentration, increment in high-density lipoprotein (HDL) concentration, reduced aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP) and bilirubin concentration in the serum. The study concluded that Curcumin can be used to overcome some health problems such as diabetes, obesity and cardiovascular diseases.