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The Effects of Haematococcus Pluvialis Astaxanthin on Streptozotocin-Induced Diabetes in Rats

Yongchao Li, Bo Zhang, Qinghua He, and Ruixue Liu
Research Institute for Science and Technology of Functional Food, Beijing Union University, China, 100191
Abstract—We evaluated the effects of Haematococcus pluvialis astaxanthinon on streptozotocin-induced diabetes and its mechanisms in rats. Method: Adult male SD rats were supplied. The rats were randomly divided into six groups (12/group): the control group, the model group, Metformin hydrochloride group and Haematococcus pluvialis low, medium and high dose groups. All groups rats, except control group, were modeled to diabetes by injecting Streptozotocin (STZ). Metformin hydrochloride group (metformin (0.285g/kg BW). The blood samples of rats were collected and the studying targets including anti-inflammatory and antioxidant capacity were measured. Results: compared to the model group, The body weight as well as water intake and diet intake were significantly inhibited. Activity of antioxidant enzymes, included SOD and GSH-PX were increased significantly. MDA content were decreased significantly. Blood glucose were decreased significantly. The levels of Cytokines TNF-α, IL-1β were decreased significantly. The levels of TC and TG were decreased significantly and the levels of HDL were increased significantly but the levels of LDL were decreased significantly .Conclusion: Haematococcus pluvialis astaxanthin attenuated streptozotocin-induced diabetes in rats. The possible mechanisms at least include both an anti-inflammatory effect and improvement of antioxidant capacity.
 
Index Terms—haematococcus pluvialis, astaxanthin, blood glucose, diabetes; rat

Cite: Yongchao Li, Bo Zhang, Qinghua He, and Ruixue Liu, "The Effects of Haematococcus Pluvialis Astaxanthin on Streptozotocin-Induced Diabetes in Rats," International Journal of Food Engineering, Vol. 4, No. 2, pp. 157-160, June 2018. doi: 10.18178/ijfe.4.2.157-160

 

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