Abstract—Immunosensor methods are worldwide applied methods for detecting and quantifying food- and feed contaminants, toxicants or pathogens in food matrices. Immunosensor methods are rapid and cost-effective methods that could reach high sensitivity and selectivity. In this study, chemically and biologically produced gold nanoparticles (AuNPs) were utilized to enhance signal sensitivity in case of a Quartz Crystal Microbalance with Impedance (QCM-I) measurement system. Biological production of AuNPs is a green technology; therefore its importance relies on less environmental impact. Results showed that biologically produced AuNPs are comparable with chemically produced nanoparticles in terms of signal sensitivity enhancement. Several biologically produced AuNPs were used with different origin and different median particle size. Therefore each of them has different physical properties. Results showed that bio AuNPs can enhance sensor sensitivity and also can enhance the accuracy of the measurement by decreasing the standard deviation of the signals; the effect depends on the physical properties of the applied bio AuNP.
 

Index Terms—immunosensor, quartz crystal microbalance, gold nanoparticle, green technology, sensitization

Cite: Ádám G. Nagy, Nóra Adányi, István Szendrő, George Szakacs, Viktória Bódai, István Lagzi, and Eszter Tóth-Szeles, "Development of a Quartz Crystal Microbalance with Impedance Measurement with Bio-Gold Nanoparticles for Enhanced Sensitivity," International Journal of Food Engineering, Vol. 4, No. 2, pp.122-126, June 2018. doi: 10.18178/ijfe.4.2.122-126